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Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients.

Cancer cell - 13 Aug 2018

Kahles André, Lehmann Kjong-Van, Toussaint Nora C, Hüser Matthias, Stark Stefan G, Sachsenberg Timo, Stegle Oliver, Kohlbacher Oliver, Sander Chris, Rätsch Gunnar

Abstract excerpt

Our comprehensive analysis of alternative splicing across 32 The Cancer Genome Atlas cancer types from 8,705 patients detects alternative splicing events and tumor variants by reanalyzing RNA and whole-exome sequencing data. Tumors have up to 30% more alternative splicing events than normal samples. Association analysis of somatic variants with alternative splicing events confirmed known trans associations with...

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Alternative Splicing
Cancer Genomics and Diagnostics
Exome Sequencing
Neoplasms
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Quantitative Trait Loci

RNA Research and Splicing

Sequence Analysis, RNA

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Identifiers

PMID: 30078747
DOI: 10.1016/j.ccell.2018.07.001
PMCID: PMC9844097

Genes

TADA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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