Article

FTO suppresses STAT3 activation and modulates proinflammatory interferon-stimulated gene expression

2021-07-24

Abstract excerpt

Signaling initiated by type I interferon (IFN) results in the induction of hundreds of IFN-stimulated genes (ISGs). The type I IFN response is important for antiviral restriction, but aberrant activation of this response can lead to inflammation and autoimmunity. Regulation of this response is incompletely understood. We previously reported that the mRNA modification m 6 A and its deposition enzymes, METTL3 and M...

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Literature Corpus work: d71238d8-b668-52e8-9c3b-c21563ddecb2
DOI: 10.1101/2021.07.23.453596

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