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METTL3 regulates PRRSV replication by suppressing interferon beta through autophagy-mediated IKKε degradation

23 Jun 2025

Abstract excerpt

ABSTRACT Methyltransferase-like-3 (METTL3)-mediated N6-methyladenosine (m 6 A) modification of messenger RNAs plays a pivotal role in regulating innate immune responses, either promoting or combating virus replication. However, the biological function of METTL3 during porcine reproductive and respiratory syndrome virus (PRRSV) infection remains unclear. In this study, we found that PRRSV infection reprograms m 6...

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Cancer-related molecular mechanisms research
RNA modifications and cancer
Viral-associated cancers and disorders

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40548751
DOI: 10.1128/jvi.00098-25

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