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Article

Dynamic RNA modifications in disease.

Current opinion in genetics & development - 1 Jun 2014

Klungland Arne, Dahl John Arne

Abstract excerpt

While the presence of 6-methyladenosine (m6A) modifications in mRNA was noted several decades ago, the first enzyme reversing this modification was identified very recently. Today we know of two methyltransferases introducing m6A in mRNA--METTL3 and METTL14--and two demethylases that remove it have been identified-FTO (ALKBH9) and ALKBH5. The conserved role of m6A seems to relate to meiosis, and mice lacking...

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Adenosine
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Diabetes Mellitus, Type 2
Dioxygenases
Membrane Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Methyltransferases

Source

Identifiers

PMID: 25005745
DOI: 10.1016/j.gde.2014.05.006

Genes

FTO
ALKBH5
METTL14
METTL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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