Article

Distinct Genomic Features Across Cytolytic Subgroups in Skin Melanoma

2020-09-15

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Skin melanoma is a highly immunogenic cancer with extensive genetic and transcriptional diversity. Despite the enthusiastic clinical results seen in advanced-stage metastatic melanoma patients treated with immune checkpoint inhibition, a subgroup of them later relapse and develop acquired resistance. The intratumoral immune cytolytic activity (CYT) reflects the...

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Literature Corpus work: d70cade0-c957-57b0-8a38-df3b909752c9
DOI: 10.21203/rs.3.rs-74123/v1

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