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Article

Genomic landscape of the immunogenicity regulation in skin melanomas with diverse tumor mutation burden.

Frontiers in immunology - 1 Jan 2022

Georgoulias George, Zaravinos Apostolos

Abstract excerpt

Skin melanoma cells are tightly interconnected with their tumor microenvironment (TME), which influences their initiation, progression, and sensitivity/resistance to therapeutic interventions. An immune-active TME favors patient response to immune checkpoint inhibition (ICI), but not all patients respond to therapy. Here, we assessed differential gene expression in primary and metastatic tumors from the TCGA-SKCM...

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Source

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Identifiers

PMID: 36389735
DOI: 10.3389/fimmu.2022.1006665
PMCID: PMC9650672

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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