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Genomic landscape of the immunogenicity regulation in skin melanomas with diverse tumor mutation burden.

Frontiers in immunology - 1 Jan 2022

Georgoulias George, Zaravinos Apostolos

Abstract excerpt

Skin melanoma cells are tightly interconnected with their tumor microenvironment (TME), which influences their initiation, progression, and sensitivity/resistance to therapeutic interventions. An immune-active TME favors patient response to immune checkpoint inhibition (ICI), but not all patients respond to therapy. Here, we assessed differential gene expression in primary and metastatic tumors from the TCGA-SKCM...

Topics

Humans
Melanoma
Skin Neoplasms
Biomarkers, Tumor
Genomics
Mutation
Tumor Microenvironment
Melanoma, Cutaneous Malignant

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 36389735
DOI: 10.3389/fimmu.2022.1006665
PMCID: PMC9650672

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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