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Article

Molecular and genetic properties of tumors associated with local immune cytolytic activity.

Cell - 15 Jan 2015

Rooney Michael S, Shukla Sachet A, Wu Catherine J, Getz Gad, Hacohen Nir

Abstract excerpt

How the genomic landscape of a tumor shapes and is shaped by anti-tumor immunity has not been systematically explored. Using large-scale genomic data sets of solid tissue tumor biopsies, we quantified the cytolytic activity of the local immune infiltrate and identified associated properties across 18 tumor types. The number of predicted MHC Class I-associated neoantigens was correlated with cytolytic activity and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25594174
DOI: 10.1016/j.cell.2014.12.033
PMCID: PMC4856474

Genes

CASP8

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