Article

A cross-scale multimodal framework identifies clinically actionable immunotherapy biomarkers in melanoma through bulk to single-cell and spatial transcriptomics integration

2025-09-22

Abstract excerpt

<title>Abstract</title> <p> Background Melanoma, a type of skin cancer that can spread to other parts of the body, currently lacks highly precise individualized treatment options. Methods We performed multi-omics integration on The Cancer Genome Atlas Skin Cutaneous Melanoma (TCGA-SKCM) cohort to identify melanoma molecular subtypes. The identified genes were validated in independent meta cohorts from GEO, follo...

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Literature Corpus work: ebb97193-49bb-540d-86d2-c8dd49a23685
DOI: 10.21203/rs.3.rs-7167024/v1

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