Article

Specific Aneuploidies Predict Immune Evasion and Poor Immunotherapy Response in Melanoma

2026-04-15

Abstract excerpt

Melanoma is one of the leading cancer types treated with immune checkpoint blockade (ICB), yet a substantial proportion of patients fail to respond. While tumor mutational burden and PD-L1 expression are established ICB biomarkers, they leave large gaps in predictive accuracy. Somatic copy number alterations (SCNAs) are pervasive in melanoma but their role in shaping the tumor immune microenvironment (TME) and pre...

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Literature Corpus work: c65c37dc-21af-5f16-862d-f4a81dcbbc13
DOI: 10.64898/2026.04.12.718039

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