Article
Mammalian PIG-X and yeast Pbn1p are the essential components of glycosylphosphatidylinositol-mannosyltransferase I.
Molecular biology of the cell - 1 Mar 2005
Ashida Hisashi, Hong Yeongjin, Murakami Yoshiko, Shishioh Nobue, Sugimoto Nakaba, Kim Youn Uck, Maeda Yusuke, Kinoshita Taroh
Abstract excerpt
Within the endoplasmic reticulum (ER), mannoses and glucoses, donated from dolichol-phosphate-mannose and -glucose, are transferred to N-glycan and GPI-anchor precursors, and serine/threonine residues in many proteins. Glycosyltransferases that mediate these reactions are ER-resident multitransmembrane proteins with common characteristics, forming a superfamily of >10 enzymes. Here, we report an essential...
Topics
- Animals
- Anti-Infective Agents
- Base Sequence
- Blotting, Western
- CD59 Antigens
- CHO Cells
- Catalysis
- Cell Line
- Cell Separation
- Cell Survival
- Cloning, Molecular