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Article

Reducing Fatty Acid Oxidation Improves Cancer-free Survival in a Mouse Model of Li-Fraumeni Syndrome.

Cancer prevention research (Philadelphia, Pa.) - 1 Jan 2021

Wang Ping-Yuan, Ma Jin, Li Jie, Starost Matthew F, Wolfgang Michael J, Singh Komudi, Pirooznia Mehdi, Kang Ju-Gyeong, Hwang Paul M

Abstract excerpt

Germline mutations of TP53, which cause the cancer predisposition disorder Li-Fraumeni syndrome (LFS), can increase mitochondrial activity as well as fatty acid β-oxidation (FAO) in mice. Increased fatty acid metabolism can promote cancer malignancy, but its specific contribution to tumorigenesis in LFS remains unclear. To investigate this, we crossed LFS mice carrying the p53 R172H knock-in mutation (p53172H/H ,...

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Identifiers

PMID: 32958587
DOI: 10.1158/1940-6207.CAPR-20-0368
PMCID: PMC7981282

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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