USP30 deubiquitylates mitochondrial Parkin substrates and restricts apoptotic cell death

Abstract excerpt

Mitochondria play a pivotal role in the orchestration of cell death pathways. Here, we show that the control of ubiquitin dynamics at mitochondria contributes to the regulation of apoptotic cell death. The unique mitochondrial deubiquitylase, USP30, opposes Parkin‐dependent ubiquitylation of TOM20, and its depletion enhances depolarization‐induced cell death in Parkin‐overexpressing cells. Importantly, USP30 also...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Autophagy in Disease and Therapy
• Share to Mitochondrial Function and Pathology
• Share to Ubiquitin and proteasome pathways