Article

USP30 inhibition induces mitophagy and reduces oxidative stress in parkin-deficient human neurons

2023-01-19

Abstract excerpt

<title>Abstract</title> <p>Ubiquitination of mitochondrial proteins plays an important role in the cellular regulation of mitophagy. The E3 ubiquitin ligase parkin (encoded by <italic>PARK2</italic>) and the ubiquitin-specific protease 30 (USP30) have both been reported to regulate ubiquitination of outer mitochondrial proteins and thereby mitophagy. Loss of E3 ligase activity is thought to be pathogenic in both...

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Literature Corpus work: a54c81f7-f5d7-5c6d-8682-b8cb5eea0436
DOI: 10.21203/rs.3.rs-2356942/v1

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