Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dual role of USP30 in controlling basal pexophagy and mitophagy

12 Jun 2018

Abstract excerpt

USP30 is an integral protein of the outer mitochondrial membrane that counteracts PINK1 and Parkin-dependent mitophagy following acute mitochondrial depolarisation. Here, we use two distinct mitophagy reporter systems to reveal tonic suppression by USP30, of a PINK1-dependent component of basal mitophagy in cells lacking detectable Parkin. We propose that USP30 acts upstream of PINK1 through modulation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Genetics and Neurodevelopmental Disorders
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29895712
DOI: 10.15252/embr.201745595

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dual role of USP30 in controlling basal pexophagy and mitophagyPMID 29895712Read ↗

Mechanisms of mitophagy: PINK1, Parkin, USP30 and beyondSemantic proximity Read ↗

A novel USP30 inhibitor recapitulates genetic loss of USP30 and sets the trigger for PINK1-PARKIN amplification of mitochondrial ubiquitylationSemantic proximity Read ↗

USP30 inhibition improves mitochondrial health through both PINK1-dependent and independent mechanismsSemantic proximity Read ↗

USP30 deubiquitylates mitochondrial Parkin substrates and restricts apoptotic cell deathSemantic proximity Read ↗

Benchmarking a highly selective USP30 inhibitor for enhancement of mitophagy and pexophagySemantic proximity Read ↗

Organelle Turnover: A USP30 Safety Catch Restrains the Trigger for Mitophagy and PexophagySemantic proximity Read ↗

USP30 inhibition induces mitophagy and reduces oxidative stress in parkin-deficient and CCCP-stressed human iPSC-derived neuronsSemantic proximity Read ↗

FBXO7/ntc and USP30 antagonistically set the ubiquitination threshold for basal mitophagy and provide a target for Pink1 phosphorylation in vivoSemantic proximity Read ↗

USP30 inhibition induces mitophagy and reduces oxidative stress in parkin-deficient human neuronsSemantic proximity Read ↗

USP8 Down-Regulation Promotes Parkin-Independent Mitophagy in the Drosophila Brain and in Human NeuronsSemantic proximity Read ↗

FBXO7/ntc and USP30 antagonistically set the ubiquitination threshold for basal mitophagy and provides a target for Pink1 phosphorylation <i>in vivo</i>Semantic proximity Read ↗

USP8 inhibition promotes Parkin-independent mitophagy in the <i>Drosophila</i> brain and in human neuronsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.