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Mitochondrial DNA Instability and Neuroinflammation: Connecting the Dots Between Base Excision Repair and Neurodegenerative Disease

2025-12-22

Abstract excerpt

Neurons have exceptionally high energy demands, sustained by thousands to millions of mitochondria per cell. Each mitochondrion depends on the integrity of its mitochondrial DNA (mtDNA), which encodes essential electron transport chain (ETC) subunits required for oxidative phosphorylation (OXPHOS). The continuous, high-level production of ATP through OXPHOS generates reactive oxygen species (ROS), posing a signifi...

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Literature Corpus work
2e2e06e2-0857-55ce-878c-5019a6adb397
DOI
10.20944/preprints202512.1817.v1
Open publication

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