Article

Gene expression adaptation of metastases to their host tissue

2024-12-20

Abstract excerpt

The adaptation of metastatic cells to their host tissue critically determines the pathogenicity of a cancer and therefore patient survival. Yet, it remains elusive to what extent the host environment drives gene expression programs in metastatic cells. Here we identify adaptive mechanisms that enable metastases to establish themselves in a novel tissue context. We performed single-cell RNA-sequencing on malignant...

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Literature Corpus work: 693a8250-fd85-5f15-a4b9-bfe437ae8c4a
DOI: 10.1101/2024.12.18.629130

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