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Article

Microenvironment-Driven Reprogramming in Colorectal Cancer Liver Metastasis: Metabolic, Phenotypic, and Immune Adaptation.

International journal of molecular sciences - 11 Jul 2026

Mu Xiaoli, Meng Wenjun, Zheng Lingnan

Abstract excerpt

Liver metastasis is a major cause of mortality in patients with metastatic colorectal cancer and reflects the selective pressures imposed by the hepatic niche. This review summarizes how the liver microenvironment may reshape disseminated colorectal cancer cells through three interconnected programs: metabolic reprogramming, phenotypic plasticity, and immune evasion. Metabolically, metastatic cells adapt to the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42511550
DOI: 10.3390/ijms27146206
PMCID: PMC13410216

Genes

HGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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