Article

Endogenous cell competition kills pathogenic <i>de novo</i> mutant cells but declines under pH stress

2026-04-29

Abstract excerpt

Although endogenous cell competition safeguards embryonic development by eliminating unfit cells, the intrinsic origins of unfitness remain unclear. Here, zebrafish whole-genome sequencing and imaging reveal that endogenous cell competition removes cells with spontaneous de novo mutations in key developmental signalling pathways and in human disease-associated genes, such as those associated with Alzheimer’s dise...

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Literature Corpus work: d6f11aa5-0289-5da5-94a4-f0d524878c11
DOI: 10.64898/2026.04.27.721036

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