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Article

Intercellular competition and the inevitability of multicellular aging

30 Oct 2017

Abstract excerpt

Current theories attribute aging to a failure of selection, due to either pleiotropic constraints or declining strength of selection after the onset of reproduction. These theories implicitly leave open the possibility that if senescence-causing alleles could be identified, or if antagonistic pleiotropy could be broken, the effects of aging might be ameliorated or delayed indefinitely. These theories are built on...

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PMID: 29087299
DOI: 10.1073/pnas.1618854114

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