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Article

Cathepsin B protease mediates high population density-induced mutagenesis to drive genome evolution and competitive growth.

Nature communications - 4 May 2026

Yu Bin, Suehiro Yuji, Johnson Bryan J, Lee Eui-Seung, Li Dongdong, Huang Yawen, Johnson Joshua, Ou Guangshuo, DeGregori James, Mitani Shohei, Xue Ding

Abstract excerpt

Density-dependent population regulation is widespread in the animal kingdom, but the underlying molecular mechanisms remain poorly understood. Here, we show that C. elegans animals respond to crowding stress by secreting CPR-4, a homologue of human cathepsin B cysteine protease, leading to chromosomal DNA damage in germ cells and high density-induced deficiencies that include increased embryonic lethality and...

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Identifiers

PMID: 42082483
DOI: 10.1038/s41467-026-72521-6
PMCID: PMC13319838

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