Article

Cysteine protease cathepsin B promotes high population density-induced mutagenesis, driving genome evolution and competitive growth in response to the crowding stress

2025-12-25

Abstract excerpt

In a wide variety of species from invertebrates to mammals, overpopulation has been shown to induce low fertility and high mortality. Although density-dependent population regulation is widespread in the animal kingdom, the underlying molecular mechanisms remain poorly understood. We show here that C. elegans animals respond to the crowding stress by secreting CPR-4, a homologue of human cathepsin B cysteine prot...

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Literature Corpus work: f94ffda9-8098-502a-b4b7-71676fd5dfa0
DOI: 10.64898/2025.12.22.696062

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