Article

Large-scale transcriptomic meta-analysis identifies novel therapeutic targets for ulcerative colitis

2026-04-24

Abstract excerpt

Ulcerative colitis (UC) is a chronic inflammatory bowel disease for which the vast majority of the approved therapies target the immune system. We aimed to identify consistently dysregulated genes and pathways across independent UC transcriptomic cohorts, distinguishing constitutive from inflammation-dependent changes. We performed a random-effects meta-analysis of 14 microarray datasets from the Gene Expression O...

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Literature Corpus work: d6ee361b-26a1-55cb-bc2b-ae5a708ce7ed
DOI: 10.64898/2026.04.22.719865

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