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Article

Precision therapy for ulcerative colitis: insights from mitochondrial dysfunction interacting with the immune microenvironment

4 Jul 2024

Abstract excerpt

Background: Accumulating evidence reveals mitochondrial dysfunction exacerbates intestinal barrier dysfunction and inflammation. Despite the growing knowledge of mitochondrial dysfunction and ulcerative colitis (UC), the mechanism of mitochondrial dysfunction in UC remains to be fully explored. Methods: We integrated 1137 UC colon mucosal samples from 12 multicenter cohorts worldwide to create a normalized...

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PMID: 39026683
DOI: 10.3389/fimmu.2024.1396221

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