Article
The IBD interactome: an integrated view of aetiology, pathogenesis and therapy.
Nature reviews. Gastroenterology & hepatology - 1 Dec 2017
de Souza Heitor S P, Fiocchi Claudio, Iliopoulos Dimitrios
Abstract excerpt
Crohn's disease and ulcerative colitis are prototypical complex diseases characterized by chronic and heterogeneous manifestations, induced by interacting environmental, genomic, microbial and immunological factors. These interactions result in an overwhelming complexity that cannot be tackled by studying the totality of each pathological component (an '-ome') in isolation without consideration of the interaction...
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