Article
A functional genomics predictive network model identifies regulators of inflammatory bowel disease.
Nature genetics - 1 Oct 2017
Peters Lauren A, Perrigoue Jacqueline, Mortha Arthur, Iuga Alina, Song Won-Min, Neiman Eric M, Llewellyn Sean R, Di Narzo Antonio, Kidd Brian A, Telesco Shannon E, Zhao Yongzhong, Stojmirovic Aleksandar, Sendecki Jocelyn, Shameer Khader, Miotto Riccardo, Losic Bojan, Shah Hardik, Lee Eunjee, Wang Minghui, Faith Jeremiah J, Kasarskis Andrew, Brodmerkel Carrie, Curran Mark, Das Anuk, Friedman Joshua R, Fukui Yoshinori, Humphrey Mary Beth, Iritani Brian M, Sibinga Nicholas, Tarrant Teresa K, Argmann Carmen, Hao Ke, Roussos Panos, Zhu Jun, Zhang Bin, Dobrin Radu, Mayer Lloyd F, Schadt Eric E
Abstract excerpt
A major challenge in inflammatory bowel disease (IBD) is the integration of diverse IBD data sets to construct predictive models of IBD. We present a predictive model of the immune component of IBD that informs causal relationships among loci previously linked to IBD through genome-wide association studies (GWAS) using functional and regulatory annotations that relate to the cells, tissues, and pathophysiology of...
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