Article

Collective cancer cell calcium activity drives brain metastasis

2026-05-13

Abstract excerpt

Communication in multicellular networks is a cancer-intrinsic neural feature and crucial for primary brain tumor growth and resistance, but it is unclear whether brain metastases (BrM), the most common and deadliest brain malignancy, are also driven by communicating cancer networks. Using intravital two-photon microscopy in awake mice, clinical specimens, and Ca 2+ integrators, we demonstrate that brain-colonizin...

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Literature Corpus work: d6d54a74-2993-5471-8b42-c2dba9797bf7
DOI: 10.64898/2026.05.10.723715

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