Article
Machine learning identifies experimental brain metastasis subtypes based on their influence on neural circuits.
Cancer cell - 11 Sept 2023
Sanchez-Aguilera Alberto, Masmudi-Martín Mariam, Navas-Olive Andrea, Baena Patricia, Hernández-Oliver Carolina, Priego Neibla, Cordón-Barris Lluís, Alvaro-Espinosa Laura, García Santiago, Martínez Sonia, Lafarga Miguel, Lin Michael Z, Al-Shahrour Fátima, Menendez de la Prida Liset, Valiente Manuel
Abstract excerpt
A high percentage of patients with brain metastases frequently develop neurocognitive symptoms; however, understanding how brain metastasis co-opts the function of neuronal circuits beyond a tumor mass effect remains unknown. We report a comprehensive multidimensional modeling of brain functional analyses in the context of brain metastasis. By testing different preclinical models of brain metastasis from various...
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