Article

Neuronal mimicry generates an ecosystem critical for brain metastatic growth of SCLC

2021-08-10

Abstract excerpt

<h4>ABSTRACT</h4> Brain metastasis is a major cause of morbidity and mortality in cancer patients. Here we investigated mechanisms allowing small-cell lung cancer (SCLC) cells to grow in the brain. We show that SCLC cells undergo a cell state transition towards neuronal differentiation during tumor progression and metastasis, and that this neuronal mimicry is critical for SCLC growth in the brain. Mechanistically...

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Literature Corpus work: d582d2c5-40d8-57f1-a77c-88537fedef6b
DOI: 10.1101/2021.08.10.455426

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