Article

Simultaneous single cell imaging of calcium signal dynamics in breast cancer and neural cells reveals communication in a model of brain metastasis

2025-07-27

Abstract excerpt

The brain provides a unique metastatic microenvironment for breast cancer cells, where calcium signaling dynamics play critical roles in both cancer cell behavior and normal brain function. Calcium signal-mediated communication between breast cancer and neural cells has not yet been demonstrated through selective activation of breast cancer cells at the single cell level. To address this, we combined neural matric...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0f7c77b1-2325-5897-8776-2efa352a8c70
DOI: 10.1101/2025.07.23.666251

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Simultaneous single cell imaging of calcium signal dynamics in breast cancer and neural cells reveals communication in a model of brain metastasisDOI 10.1101/2025.07.23.666251Read

Collective cancer cell calcium activity drives brain metastasisSemantic proximity Read

Intraclonal Plasticity in Mammary Tumors Revealed through Large-Scale Single-Cell Resolution 3D ImagingSemantic proximity Read

Single-cell mapping links neurogenesis and angiogenesis in aggressive breast cancerSemantic proximity Read

Decoding Single Cell Morphology in Osteotropic Breast Cancer Cells for Dissecting Their Migratory, Molecular and Biophysical HeterogeneitySemantic proximity Read

An Emerging Role for Calcium Signaling in Cancer-Associated FibroblastsSemantic proximity Read

Global and single-cell proteomics view of the co-evolution between neural progenitors and breast cancer cells in a co-culture modelSemantic proximity Read

Breast cancer interactions with osteoclasts generate osteoclast-tumor hybrid-like cells through dynamic non-canonical cell fusion and cell-in-cell processesSemantic proximity Read

3D geometry orchestrates the transcriptional landscape of metastatic neuroblastoma cells in a multicellular in vitro bone modelSemantic proximity Read

A clinically applicable connectivity signature for glioblastoma includes the tumor network driver CHI3L1Semantic proximity Read

Pericyte-tumor crosstalk facilitates metastatic tumor cell latency through PIEZO1-activated lysophospholipid transferSemantic proximity Read

Trimodal brain-wide ultrasound imaging of brain-tumor interactionSemantic proximity Read