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Article

CSPα knockout causes neurodegeneration by impairing SNAP-25 function.

The EMBO journal - 15 Feb 2012

Sharma Manu, Burré Jacqueline, Bronk Peter, Zhang Yingsha, Xu Wei, Südhof Thomas C

Abstract excerpt

At a synapse, the synaptic vesicle protein cysteine-string protein-α (CSPα) functions as a co-chaperone for the SNARE protein SNAP-25. Knockout (KO) of CSPα causes fulminant neurodegeneration that is rescued by α-synuclein overexpression. The CSPα KO decreases SNAP-25 levels and impairs SNARE-complex assembly; only the latter but not the former is reversed by α-synuclein. Thus, the question arises whether the...

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Identifiers

PMID: 22187053
DOI: 10.1038/emboj.2011.467
PMCID: PMC3280561

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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