Article

Cryo-EM structures of Tau filaments from the brains of mice transgenic for human mutant P301S Tau

2023-09-01

Abstract excerpt

<h4>ABSTRACT</h4> Mice transgenic for human mutant P301S tau are widely used as models for human tauopathies. They develop neurodegeneration and abundant filamentous inclusions made of human mutant four-repeat tau. Here we used electron cryo-microscopy (cryo-EM) to determine the structures of tau filaments from the brains of Tg2541 and PS19 mice. Both lines express human P301S tau (0N4R for Tg2541 and 1N4R for PS...

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Literature Corpus work: d6c0ccd7-6687-527e-bb64-9b0fd833d76b
DOI: 10.1101/2023.08.31.555656

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