Article
Tau filament formation in transgenic mice expressing P301L tau.
The Journal of biological chemistry - 5 Jan 2001
Götz J, Chen F, Barmettler R, Nitsch R M
Abstract excerpt
Mutations in the microtubule-associated protein tau, including P301L, are genetically coupled to hereditary frontotemporal dementia with parkinsonism linked to chromosome 17. To determine whether P301L is associated with fibril formation in mice, we expressed the longest human tau isoform, human tau40, with this mutation in transgenic mice by using the neuron-specific mouse Thy1.2 promoter. We obtained mice with...
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