Multivariate Genome-wide Association Analysis of a Cytokine Network Reveals Variants with Widespread Immune, Haematological, and Cardiometabolic Pleiotropy.

doi:10.1016/j.ajhg.2019.10.001

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Article

Multivariate Genome-wide Association Analysis of a Cytokine Network Reveals Variants with Widespread Immune, Haematological, and Cardiometabolic Pleiotropy.

American journal of human genetics - 5 Dec 2019

Nath Artika P, Ritchie Scott C, Grinberg Nastasiya F, Tang Howard Ho-Fung, Huang Qin Qin, Teo Shu Mei, Ahola-Olli Ari V, Würtz Peter, Havulinna Aki S, Santalahti Kristiina, Pitkänen Niina, Lehtimäki Terho, Kähönen Mika, Lyytikäinen Leo-Pekka, Raitoharju Emma, Seppälä Ilkka, Sarin Antti-Pekka, Ripatti Samuli, Palotie Aarno, Perola Markus, Viikari Jorma S, Jalkanen Sirpa, Maksimow Mikael, Salmi Marko, Wallace Chris, Raitakari Olli T, Salomaa Veikko, Abraham Gad, Kettunen Johannes, Inouye Michael

Abstract excerpt

Cytokines are essential regulatory components of the immune system, and their aberrant levels have been linked to many disease states. Despite increasing evidence that cytokines operate in concert, many of the physiological interactions between cytokines, and the shared genetic architecture that underlies them, remain unknown. Here, we aimed to identify and characterize genetic variants with pleiotropic effects...

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Identifiers

PMID: 31679650
DOI: 10.1016/j.ajhg.2019.10.001
PMCID: PMC6904835

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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