Article
Identifying high-impact variants and genes in exomes of Ashkenazi Jewish inflammatory bowel disease patients.
Nature communications - 20 Apr 2023
Wu Yiming, Gettler Kyle, Kars Meltem Ece, Giri Mamta, Li Dalin, Bayrak Cigdem Sevim, Zhang Peng, Jain Aayushee, Maffucci Patrick, Sabic Ksenija, Van Vleck Tielman, Nadkarni Girish, Denson Lee A, Ostrer Harry, Levine Adam P, Schiff Elena R, Segal Anthony W, Kugathasan Subra, Stenson Peter D, Cooper David N, Philip Schumm L, Snapper Scott, Daly Mark J, Haritunians Talin, Duerr Richard H, Silverberg Mark S, Rioux John D, Brant Steven R, McGovern Dermot P B, Cho Judy H, Itan Yuval
Abstract excerpt
Inflammatory bowel disease (IBD) is a group of chronic digestive tract inflammatory conditions whose genetic etiology is still poorly understood. The incidence of IBD is particularly high among Ashkenazi Jews. Here, we identify 8 novel and plausible IBD-causing genes from the exomes of 4453 genetically identified Ashkenazi Jewish IBD cases (1734) and controls (2719). Various biological pathway analyses are...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.