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Inflammatory Bowel Disease: Genetics, Epigenetics, and Pathogenesis

2 Nov 2015

Abstract excerpt

Inflammatory bowel diseases (IBDs) are complex, multifactorial disorders characterized by chronic relapsing intestinal inflammation. Although etiology remains largely unknown, recent research has suggested that genetic factors, environment, microbiota, and immune response are involved in the pathogenesis. Epidemiological evidence for a genetic contribution is defined: 15% of patients with Crohn's Disease (CD)...

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PMID: 26579126
DOI: 10.3389/fimmu.2015.00551

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