Article

The energetic and allosteric landscape for KRAS inhibition

2022-12-08

Abstract excerpt

Thousands of proteins have now been genetically-validated as therapeutic targets in hundreds of human diseases. However, very few have actually been successfully targeted and many are considered ‘undruggable’. This is particularly true for proteins that function via protein-protein interactions: direct inhibition of binding interfaces is difficult, requiring the identification of allosteric sites. However, most pr...

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Literature Corpus work: abb243b2-55ef-5163-9e9f-95535b0160da
DOI: 10.1101/2022.12.06.519122

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