Back to search

Article

Sedentary behavior may accelerate aging through impact on epigenome and transcriptome: lessons from muscle inactivation in <i>Drosophila</i> larvae

2023-08-28

Abstract excerpt

<h4>Aim</h4> The biological mechanisms linking sedentary lifestyles and metabolic derangements are incompletely understood. Our animal model mimics sedentary behavior during early life, enabling us to explore the associated chromatin epigenetic and transcriptomic landscapes. <h4>Methods</h4> Drosophila larvae carrying a temperature-sensitive mutation in the shibire 1 ( shi ) gene were used. shi homozygous mut...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
d699b608-8929-5013-95de-71c52e0f5eeb
DOI
10.1101/2023.08.28.555053
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Sedentary behavior may accelerate aging through impact on epigenome and transcriptome: lessons from muscle inactivation in <i>Drosophila</i> larvaeDOI 10.1101/2023.08.28.555053
Chromatin-modifying genetic interventions suppress age-associated transposable element activation and extend life span in Drosophila.Semantic proximity
Adult-specific trimethylation of histone H3 lysine 4 is prone to dynamic changes with aging in <i>C. elegans</i> somatic cellsSemantic proximity
Modeling exercise using optogenetically contractible <i>Drosophila</i> larvaeSemantic proximity
Muscle-Specific Upregulation of Timeless Mediates Exercise-Induced Amelioration of Age-Related Circadian Rhythm Disruption and Cardiac Dysfunction in DrosophilaSemantic proximity
The Role of Genetic Variation in Shaping Phenotypic Responses to Diet in Aging <i>Drosophila melanogaster</i>Semantic proximity
Age-related change in γH2AX of Drosophila muscle: its significance as a marker for muscle damage and longevity.Semantic proximity
Mesodermal-specific <i>MECP2</i> expression in <i>Drosophila</i> induces visceral and skeletal muscle defects rescued by butyrate supplementationSemantic proximity
HLH-30/TFEB is necessary for chromatin reorganization and maintenance of cell quiescence during starvation in <i>C. elegans</i>Semantic proximity
A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageingSemantic proximity
Exploring the ageing methylome in the model insect, <i>Nasonia vitripennis</i>Semantic proximity
Locus-specific H3K9me3 gain in aged somatic tissues in Caenorhabditis elegansSemantic proximity
Genetic Networks Underlying Natural Variation in Basal and Induced Activity Levels in Drosophila melanogaster.Semantic proximity
Select a neighboring publication to make it the new centre.