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Article

Role of chromatin and transcriptional co-regulators in mediating p63-genome interactions in keratinocytes

29 Nov 2014

Abstract excerpt

BACKGROUND: The Transcription Factor (TF) p63 is a master regulator of epidermal development and differentiation as evident from the remarkable skin phenotype of p63 mouse knockouts. Furthermore, ectopic expression of p63 alone is sufficient to convert simple epithelium into stratified epithelial tissues in vivo and p63 is required for efficient transdifferentiation of fibroblasts into keratinocytes. However,...

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PMID: 25433490
DOI: 10.1186/1471-2164-15-1042

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