Article

Investigating the function of the hereditary spastic paraplegia protein spastin in the endomembrane system

2019-01-01

Abstract excerpt

Hereditary spastic paraplegias (HSPs) are genetically inherited neurological diseases characterised by the distal axonal degeneration of corticospinal neurons. Of the 80 genes currently associated with HSP, mutations in SPAST, encoding the protein spastin, are by far the most common cause of pathology. Spastin functions as a microtubule remodelling enzyme by using energy derived from ATP hydrolysis by its ATPase d...

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Literature Corpus work: d674e6ab-d56d-52e3-8ffe-184209c800f1
DOI: 10.17863/cam.38203

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