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Article

The AAA ATPase spastin links microtubule severing to membrane modelling.

Biochimica et biophysica acta - 1 Jan 2012

Lumb Jennifer H, Connell James W, Allison Rachel, Reid Evan

Abstract excerpt

In 1999, mutations in the gene encoding the microtubule severing AAA ATPase spastin were identified as a major cause of a genetic neurodegenerative condition termed hereditary spastic paraplegia (HSP). This finding stimulated intense study of the spastin protein and over the last decade, a combination of cell biological, in vivo, in vitro and structural studies have provided important mechanistic insights into...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21888932
DOI: 10.1016/j.bbamcr.2011.08.010

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The AAA ATPase spastin links microtubule severing to membrane modelling.PMID 21888932Read ↗

Spastin and microtubules: Functions in health and diseaseSemantic proximity Read ↗

Spastin, the protein mutated in autosomal dominant hereditary spastic paraplegia, is involved in microtubule dynamics.Semantic proximity Read ↗

Spastin couples microtubule severing to membrane traffic in completion of cytokinesis and secretion.Semantic proximity Read ↗

Recognition of C-terminal amino acids in tubulin by pore loops in Spastin is important for microtubule severing.Semantic proximity Read ↗

Functional characterization of spastin and its role in hereditary spastic paraplegiaSemantic proximity Read ↗

The Drosophila homologue of the hereditary spastic paraplegia protein, spastin, severs and disassembles microtubules.Semantic proximity Read ↗

Linking axonal degeneration to microtubule remodeling by Spastin-mediated microtubule severing.Semantic proximity Read ↗

Human spastin functions as an ATPase-independent microtubule nucleator via ring-stack formationSemantic proximity Read ↗

A newly identified NES sequence present in spastin regulates its subcellular localization and microtubule severing activity.Semantic proximity Read ↗

Investigating the function of the hereditary spastic paraplegia protein spastin in the endomembrane systemSemantic proximity Read ↗

Spastin oligomerizes into a hexamer and the mutant spastin (E442Q) redistribute the wild-type spastin into filamentous microtubule.Semantic proximity Read ↗

Conserved aromatic and basic amino acid residues in the pore region of Caenorhabditis elegans spastin play critical roles in microtubule severing.Semantic proximity Read ↗

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