Article

Functional characterization of spastin and its role in hereditary spastic paraplegia

2004-01-01

Abstract excerpt

Hereditary spastic paraplegia (HSP) is a neurodegenerative disease characterized by the spasticity of the lower limbs due to degeneration of the corticospinal tracts. The gene responsible for the most frequent form of autosomal dominant HSP encodes spastin, an ATPase belonging to the AAA family. Studies with specific antibodies indicate that spastin has both a nuclear and cytosolic localization. In human fibroblas...

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Literature Corpus work: 24f7fcae-96de-5eee-81e4-2b2100447244
DOI: 10.21954/ou.ro.0000f9d2

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