Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spastin and microtubules: Functions in health and disease

8 Mar 2007

Abstract excerpt

SPG4, the gene encoding for spastin, a member of the ATPases associated with various cellular activities (AAA) family, is mutated in around 40% of cases of autosomal dominant hereditary spastic paraplegia (AD-HSP). This group of neurodegenerative diseases is characterized by a progressive spasticity and lower limb weakness with degeneration of terminal axons in cortico-spinal tracts and dorsal columns. Spastin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neurological diseases and metabolism
Share to Hereditary Neurological Disorders
Share to Neurogenetic and Muscular Disorders Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17348041
DOI: 10.1002/jnr.21238

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spastin and microtubules: Functions in health and diseasePMID 17348041Read ↗

Spastin, the protein mutated in autosomal dominant hereditary spastic paraplegia, is involved in microtubule dynamics.Semantic proximity Read ↗

The Drosophila homologue of the hereditary spastic paraplegia protein, spastin, severs and disassembles microtubules.Semantic proximity Read ↗

Functional characterization of spastin and its role in hereditary spastic paraplegiaSemantic proximity Read ↗

The AAA ATPase spastin links microtubule severing to membrane modelling.Semantic proximity Read ↗

Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function.Semantic proximity Read ↗

Linking axonal degeneration to microtubule remodeling by Spastin-mediated microtubule severing.Semantic proximity Read ↗

A newly identified NES sequence present in spastin regulates its subcellular localization and microtubule severing activity.Semantic proximity Read ↗

Conserved aromatic and basic amino acid residues in the pore region of Caenorhabditis elegans spastin play critical roles in microtubule severing.Semantic proximity Read ↗

Investigating the function of the hereditary spastic paraplegia protein spastin in the endomembrane systemSemantic proximity Read ↗

Spastin oligomerizes into a hexamer and the mutant spastin (E442Q) redistribute the wild-type spastin into filamentous microtubule.Semantic proximity Read ↗

Interaction of two hereditary spastic paraplegia gene products, spastin and atlastin, suggests a common pathway for axonal maintenance.Semantic proximity Read ↗

[AAA ATPases and hereditary spastic paraplegia].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.