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Article

Cellular distribution and subcellular localization of spatacsin and spastizin, two proteins involved in hereditary spastic paraplegia

28 Apr 2011

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 21545838
DOI: 10.1016/j.mcn.2011.04.004

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Cellular distribution and subcellular localization of spatacsin and spastizin, two proteins involved in hereditary spastic paraplegiaPMID 21545838Read ↗

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Spastin, the protein mutated in autosomal dominant hereditary spastic paraplegia, is involved in microtubule dynamics.Semantic proximity Read ↗

A novel truncated variant in SPAST results in spastin accumulation and defects in microtubule dynamics.Semantic proximity Read ↗

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A newly identified NES sequence present in spastin regulates its subcellular localization and microtubule severing activity.Semantic proximity Read ↗

First mutation in the nuclear localization signal sequence of spastin protein identified in a patient with hereditary spastic paraplegia.Semantic proximity Read ↗

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