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Article

Interaction of two hereditary spastic paraplegia gene products, spastin and atlastin, suggests a common pathway for axonal maintenance.

Proceedings of the National Academy of Sciences of the United States of America - 11 Jul 2006

Evans Katia, Keller Christian, Pavur Karen, Glasgow Kristen, Conn Bryan, Lauring Brett

Abstract excerpt

Hereditary spastic paraplegia (HSP) is a neurodegenerative disorder that is characterized by retrograde axonal degeneration that primarily affects long spinal neurons. The disease is clinically heterogeneous, and there are >20 genetic loci identified. Here, we show a physical interaction between spastin and atlastin, two autosomal dominant HSP gene products. Spastin encodes a microtubule (MT)-severing AAA ATPase...

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Identifiers

PMID: 16815977
DOI: 10.1073/pnas.0510863103
PMCID: PMC1502289

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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