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Article

Microtubule-dependent and independent roles of spastin in lipid droplet dispersion and biogenesis.

Life science alliance - 1 Jun 2020

Tadepalle Nimesha, Robers Lennart, Veronese Matteo, Zentis Peter, Babatz Felix, Brodesser Susanne, Gruszczyk Anja V, Schauss Astrid, Höning Stefan, Rugarli Elena I

Abstract excerpt

Lipid droplets (LDs) are metabolic organelles that store neutral lipids and dynamically respond to changes in energy availability by accumulating or mobilizing triacylglycerols (TAGs). How the plastic behavior of LDs is regulated is poorly understood. Hereditary spastic paraplegia is a central motor axonopathy predominantly caused by mutations in SPAST, encoding the microtubule-severing protein spastin. The...

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Identifiers

PMID: 32321733
DOI: 10.26508/lsa.202000715
PMCID: PMC7184029

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Microtubule-dependent and independent roles of spastin in lipid droplet dispersion and biogenesis.PMID 32321733Read ↗

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