Article
Spastin couples microtubule severing to membrane traffic in completion of cytokinesis and secretion.
Traffic (Copenhagen, Denmark) - 1 Jan 2009
Connell James W, Lindon Catherine, Luzio J Paul, Reid Evan
Abstract excerpt
Mutations in the gene encoding the microtubule (MT)-severing protein spastin are the most common cause of hereditary spastic paraplegia, a genetic condition in which axons of the corticospinal tracts degenerate. We show that not only does endogenous spastin colocalize with MTs, but that it is also located on the early secretory pathway, can be recruited to endosomes and is present in the cytokinetic midbody....
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