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Article

Hormone Selectivity in Thyroid Hormone Receptors

2001-03-01

Abstract excerpt

Separate genes encode thyroid hormone receptor subtypes TRα (NR1A1) and TRβ (NR1A2). Products from each of these contribute to hormone action, but the subtypes differ in tissue distribution and physiological response. Compounds that discriminate between these subtypes in vivo may be useful in treating important medical problems such as obesity and hypercholesterolemia. We previously determined the crystal structur...

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Identifiers and source

Literature Corpus work
d66d206c-1514-58b2-aa8a-d3be30a12b0f
DOI
10.1210/me.15.3.398
Open publication

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Hormone Selectivity in Thyroid Hormone ReceptorsDOI 10.1210/me.15.3.398
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