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Article

Revealing a Mutant-Induced Receptor Allosteric Mechanism for the Thyroid Hormone Resistance

1 Oct 2019

Abstract excerpt

Resistance to thyroid hormone (RTH) is a clinical disorder without specific and effective therapeutic strategy, partly due to the lack of structural mechanisms for the defective ligand binding by mutated thyroid hormone receptors (THRs). We herein uncovered the prescription drug roxadustat as a novel THRβ-selective ligand with therapeutic potentials in treating RTH, thereby providing a small molecule tool...

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PMID: 31655060
DOI: 10.1016/j.isci.2019.10.002

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