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Article

Structure-Guided Approach to Relieving Transcriptional Repression in Resistance to Thyroid Hormone α.

Molecular and cellular biology - 17 Feb 2022

Romartinez-Alonso Beatriz, Agostini Maura, Jones Heulyn, McLellan Jayde, Sood D Eilidh, Tomkinson Nicholas, Marelli Federica, Gentile Ilaria, Visser W Edward, Schoenmakers Erik, Fairall Louise, Privalsky Martin, Moran Carla, Persani Luca, Chatterjee Krishna, Schwabe John W R

Abstract excerpt

Mutations in thyroid hormone receptor α (TRα), a ligand-inducible transcription factor, cause resistance to thyroid hormone α (RTHα). This disorder is characterized by tissue-specific hormone refractoriness and hypothyroidism due to the inhibition of target gene expression by mutant TRα-corepressor complexes. Using biophysical approaches, we show that RTHα-associated TRα mutants devoid of ligand-dependent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34871063
DOI: 10.1128/MCB.00363-21
PMCID: PMC8852717

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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