Article
In vitro effect of Triac on resistance to thyroid hormone receptor mutants: potential basis for therapy.
Molecular and cellular endocrinology - 28 Mar 2001
Messier N, Laflamme L, Hamann G, Langlois M F
Abstract excerpt
Resistance to thyroid hormone (RTH) is a syndrome caused by a mutation in the carboxyl-terminal domain of the thyroid hormone receptor beta (TRbeta) gene. 3,5,3'-triiodothyroacetic acid (Triac) has been used on an empirical basis to treat RTH but its efficacy is still controversial. In previous studies, we demonstrated that Triac has TR isoform- and TRE-specific effects. In this report, we used five natural RTH...
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